Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	114292
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Beyond gluten-free diet: Novel therapeutic frontiers in celiac disease armamentarium
Manuscript Source	Invited Manuscript
All Author List	Sandeep K Mundhra and Rakesh K Kochhar
Funding Agency and Grant Number
Corresponding Author	Rakesh K Kochhar, DM, Professor, Department of Gastroenterology, Paras Hospital, Paras Hospital Road, Sector-22, Panchkula 134109, Haryana, India. dr_kochhar@hotmail.com
Key Words	Celiac disease; Gluten-free diet; Celiac disease pathophysiology; Celiac disease treatment; Novel therapies in celiac disease
Core Tip	Celiac disease is managed with a gluten-free diet, which is difficult to sustain and often fails to achieve full mucosal recovery. Advances in disease pathogenesis have led to novel therapies, including gluten-detoxifying enzymes, gluten-sequestering polymers, barrier stabilizers, tissue transglutaminase-2 inhibitors, human leukocyte antigen-DQ antagonists, cytokine-directed biologics, and tolerance-inducing strategies such as nanoparticle-based therapies. This review summarizes the current therapeutic pipeline, discusses the challenges of translating emerging therapies into routine practice, and highlights how future management is likely to evolve towards personalized, multimodal approaches that integrate dietary management with safe and effective adjunctive therapies.
Citation	Mundhra SK, Kochhar RK. Beyond gluten-free diet: Novel therapeutic frontiers in celiac disease armamentarium. World J Gastrointest Pharmacol Ther 2026; In press

Received	2025-09-16 06:41
Peer-Review Started	2025-09-16 06:41
First Decision by Editorial Office Director	2025-11-19 10:19
Return for Revision	2025-11-19 10:19
Revised	2025-12-01 18:37
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 00:16
Articles in Press	2026-02-03 00:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com