Publication Name	World Journal of Clinical Oncology
Manuscript ID	114298
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Microenvironment plays a critical role in modulating tumor cell dormancy: Current perspectives and potential treatment options
Manuscript Source	Invited Manuscript
All Author List	Ye-Rong Qian, Peng Liu, Hui Xu, Yi Lv, Xu-Feng Zhang and Jun-Xi Xiang
Funding Agency and Grant Number	Funding Agency Grant Number Shaanxi Innovation Capability Support Plan No. 2023KJXX-030 Shaanxi Health and Family Planning Commission Project No. 2021E018 Noncommunicable Chronic Diseases-National Science and Technology Major Project of China No. 2023ZD0502004
Corresponding Author	Jun-Xi Xiang, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yan-ta Road, Xi’an 710061, Shaanxi Province, China. xjx722@163.com
Key Words	Tumor dormancy; Tumor microenvironment; Extracellular matrix; Cancer recurrence; Metastasis
Core Tip	This article explores the critical role of the tumor microenvironment (TME) in regulating tumor dormancy, a state in which malignant cells remain viable but non-proliferative, contributing to metastasis and recurrence. We highlight the dynamic interactions within the TME, including immune cell modulation, extracellular matrix components, and metabolic factors, that maintain dormancy. The article discusses promising therapeutic strategies targeting the TME to either awaken dormant cells for treatment or maintain their quiescence, aiming to improve cancer treatment outcomes and prevent recurrence.
Citation	Qian YR, Liu P, Xu H, Lv Y, Zhang XF, Xiang JX. Microenvironment plays a critical role in modulating tumor cell dormancy: Current perspectives and potential treatment options. World J Clin Oncol 2026; In press

Received	2025-09-16 06:43
Peer-Review Started	2025-09-16 06:44
First Decision by Editorial Office Director	2025-09-28 06:51
Return for Revision	2025-09-28 06:51
Revised	2025-10-11 10:42
Publication Fee Transferred
Second Decision by Editor	2026-01-06 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-06 10:06
Articles in Press	2026-01-06 10:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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