Publication Name	World Journal of Stem Cells
Manuscript ID	114303
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Editorial
Article Title	Targeting mitochondrial quality control in osteoarthritis with GrpE-like 1-loaded synovial mesenchymal stromal/stem cell small extracellular vesicles
Manuscript Source	Invited Manuscript
All Author List	Zhuo-Jin Shi, Xiao-Mei Ying and Wei Liu
Funding Agency and Grant Number
Corresponding Author	Wei Liu, Department of Oral Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. liuwei1982@zju.edu.cn
Key Words	Osteoarthritis; Extracellular vesicles; Synovial mesenchymal stem cells; GrpE-like 1; PTEN-induced kinase 1/Parkin-mediated mitophagy
Core Tip	This editorial frames GrpE-like 1-loaded synovial extracellular vesicles as a mitochondria-centric strategy for osteoarthritis and translates bench evidence into an executable roadmap. We operationalize identity/purity panels, dual-metric dose (particles and protein), shared exposure anchors, and a mechanism-linked potency assay for lot release and comparability. Early trials should prespecify Outcome Measures in Rheumatology-Osteoarthritis Research Society International endpoints with quantitative magnetic resonance imaging cartilage thickness as an exploratory structural anchor. Transparent method registration and time-bounded regulatory messaging are emphasized to improve reproducibility, cross-study comparison, and readiness for first-in-human evaluation.
Citation	Shi ZJ, Ying XM, Liu W. Targeting mitochondrial quality control in osteoarthritis with GrpE-like 1-loaded synovial mesenchymal stromal/stem cell small extracellular vesicles. World J Stem Cells 2026; In press

Received	2025-09-16 06:47
Peer-Review Started	2025-09-16 06:47
First Decision by Editorial Office Director	2025-10-21 06:45
Return for Revision	2025-10-21 06:45
Revised	2025-11-02 10:20
Publication Fee Transferred
Second Decision by Editor	2026-01-20 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-20 09:07
Articles in Press	2026-01-20 09:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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