Publication Name	World Journal of Critical Care Medicine
Manuscript ID	114318
Country	United States

Category	Critical Care Medicine
Manuscript Type	Retrospective Cohort Study
Article Title	Predicting acute kidney injury in septic shock patients using inflammatory indices in the intensive care unit
Manuscript Source	Invited Manuscript
All Author List	Jackson Rajendran, Song-Peng Ang, Maria Jose Lorenzo-Capps, Carlos Valladares, Eunseuk Lee, Veera Jayasree Latha Bommu, George Altarcha, Svitlana Pominov, Bryan Gregory, Jia Ee Chia and Jose Iglesias
Funding Agency and Grant Number
Corresponding Author	Jose Iglesias, FASN, Department of Internal Medicine, Hackensack Meridian School of Medicine, 123 Metro Blvd, Nutley, NJ 07110, United States. jiglesias23@gmail.com
Key Words	Acute kidney injury; Septic shock; Inflammatory indices; eICU Collaborative Research Database; Principal component analysis; Machine learning; Neutrophil-to-lymphocyte ratio; Systemic immune-inflammation index; Aggregate index of systemic inflammation; Monocyte-to-lymphocyte ratio
Core Tip	Composite inflammatory markers are elevated in patients who develop acute kidney injury. However, due to heterogeneity of septic shock, multicollinearity and nonlinear relationships, these markers alone offer limited incremental predictive value. Neural network models further expounded the contribution of both clinical factors and the combined inflammatory/metabolic dimension to accurate acute kidney injury prediction, capturing complex interactions and non-linear relationships not evident in traditional regression models. Implementation of supervised and unsupervised machine learning together may offer further insights.
Citation	Rajendran J, Ang SP, Lorenzo-Capps MJ, Valladares C, Lee E, Bommu VJL, Altarcha G, Pominov S, Gregory B, Chia JE, Iglesias J. Predicting acute kidney injury in septic shock patients using inflammatory indices in the intensive care unit. World J Crit Care Med 2026; In press

Received	2025-09-16 08:12
Peer-Review Started	2025-09-16 08:12
First Decision by Editorial Office Director	2025-10-29 09:20
Return for Revision	2025-10-29 09:20
Revised	2025-11-17 04:42
Publication Fee Transferred
Second Decision by Editor	2026-01-28 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-28 11:01
Articles in Press	2026-01-28 11:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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