Publication Name	World Journal of Gastroenterology
Manuscript ID	114331
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Gao, Dong-Feng Yin, Xiang-Rong Xing, Li-Jiang Zhou and Rui Yu
Funding Agency and Grant Number	Funding Agency Grant Number Liaoning University of Traditional Chinese Medicine YXIL-2024-1700-0524
Corresponding Author	Rui Yu, Department of Technology, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Huanggu District, Shenyang 110032, Liaoning Province, China. ruiyu690923@163.com
Key Words	Xiangshaliujunzi decoction; Chemoresistance; Gastric cancer; MiR-200a-3p; ZEB1; miRNA
Core Tip	Xiangshaliujunzi decoction (XSLJZD) overcomes 5-fluorouracil (5-FU) resistance in gastric cancer by inducing PANoptosis via the miR-200a-3p/ZEB1/IRF1 pathway. In vitro, XSLJZD inhibits viability and promotes cell death. In vivo, combination with 5-FU enhances this effect. This provides a novel traditional Chinese medicine strategy for chemoresistance, though limitations include lack of standalone controls and generalizability validation.
Citation	Gao H, Yin DF, Xing XR, Zhou LJ, Yu R. MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer. World J Gastroenterol 2026; In press

Received	2025-09-28 08:45
Peer-Review Started	2025-09-28 08:46
First Decision by Editorial Office Director	2025-10-30 09:28
Return for Revision	2025-10-30 09:28
Revised	2025-11-14 07:32
Publication Fee Transferred	2025-11-20 08:19
Second Decision by Editor	2026-01-29 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-29 07:21
Articles in Press	2026-01-29 07:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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