Publication Name	World Journal of Hepatology
Manuscript ID	114346
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Effects of tenofovir amibufenamide and entecavir on estimated glomerular filtration rate in treatment-naïve patients with chronic hepatitis B
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Peng Ma, Liang Wang, Yu-Liang Zhang, Xin Wan, Qian Liu, Yu-Lun Tang, Lajpat-Rai Malhi and Shan-Fei Ge
Funding Agency and Grant Number	Funding Agency Grant Number Chinese Foundation for Hepatitis Prevention and Control Muxin Research Fund of Chronic Hepatitis B MX202418
Corresponding Author	Shan-Fei Ge, Department of Infectious Diseases, The First Affiliated Hospital of Nanchang University, No. 17 Yongwai Zheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. geshanfei2010@163.com
Key Words	Chronic hepatitis B; Tenofovir amibufenamide; Entecavir; Estimated glomerular filtration rate; Drug safety
Core Tip	This study provides the comparison of renal safety between tenofovir amibufenamide (TMF) and entecavir (ETV) in treatment-naive chronic hepatitis B patients. After propensity score matching, TMF showed significantly less decline in estimated glomerular filtration rate over 48 weeks than ETV. Baseline estimated glomerular filtration rate and triglyceride levels independently predicted abnormal renal function, highlighting TMF’s potential renal safety advantage over ETV and offering clinicians important insights for individualized antiviral therapy.
Citation	Ma SP, Wang L, Zhang YL, Wan X, Liu Q, Tang YL, Malhi LR, Ge SF. Effects of tenofovir amibufenamide and entecavir on estimated glomerular filtration rate in treatment-naïve patients with chronic hepatitis B. World J Hepatol 2025; In press

Received	2025-09-19 09:08
Peer-Review Started	2025-09-19 09:09
First Decision by Editorial Office Director	2025-09-25 09:20
Return for Revision	2025-09-26 06:08
Revised	2025-11-01 10:59
Publication Fee Transferred	2025-11-08 11:04
Second Decision by Editor	2025-12-11 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-11 08:17
Articles in Press	2025-12-11 08:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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