Publication Name	World Journal of Stem Cells
Manuscript ID	114349
Country	Bangladesh

Category	Cell & Tissue Engineering
Manuscript Type	Review
Article Title	Hurdles to overcome for mesenchymal stem cell translation from bench to bedside
Manuscript Source	Invited Manuscript
All Author List	Naiyareen Fareeza Mayeen, Umme Salma, Noor Hayaty Abu Kasim, Okba Mahmoud and Nazmul Haque
Funding Agency and Grant Number
Corresponding Author	Nazmul Haque, Chief, Head, PhD, Department of Regenerative Medicine, Concord Stem Cell Limited, 3, Sima Blossom, Road 16, Dhanmondi, Dhaka 1209, Bangladesh. haquen1983@gmail.com
Key Words	Regenerative medicine; Clinical translation; Stem cell expansion; Scaffolds; Immunomodulation; Good manufacturing practice
Core Tip	Regenerative medicine has been practiced in a variety of settings for decades. It is a multidisciplinary branch of medicine that aims at replacing degenerated cells or regenerating new human cells, tissues, or organs that have been lost or damaged due to the effects of aging, illness, or congenital defects. The main objective of regenerative medicines is to restore normal functions of the cells or tissues in patients affected by degenerative disorders. Mesenchymal stem cells (MSCs) have the potential to cure the most critical regions or take over the function of a wounded organ that is considered beyond repair using conventional therapies. In the last two decades, thousands of in vitro, in vivo, and clinical trials have been conducted using MSCs. Though the regenerative potential of MSCs has been extensively studied, there are still a lot of challenges that need to be addressed for their successful translation from bench to bedside.
Citation	Mayeen NF, Salma U, Abu Kasim NH, Mahmoud O, Haque N. Hurdles to overcome for mesenchymal stem cell translation from bench to bedside. World J Stem Cells 2025; In press

Received	2025-09-17 06:38
Peer-Review Started	2025-09-17 06:38
To Make the First Decision
Return for Revision	2025-10-11 03:10
Revised	2025-10-20 09:18
Second Decision	2025-11-20 02:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 10:14
Articles in Press	2025-11-21 10:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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