Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	114351
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Metallic elements and their molecular roles in gastric cancer: Pathogenic mechanisms and therapeutic implications
Manuscript Source	Invited Manuscript
All Author List	Li-Baihe Jing, Jie Liu, Zi-Hai Yang, Fei-Fei Yang, De-Gui Wang and Yu-Min Li
Funding Agency and Grant Number	Funding Agency Grant Number Chief Scientist Project of Gansu Province No. 22JR9KA002 Project of Gansu Provincial Department of Education No. 2021jyjbgs-02 Key Research and Development Program of Gansu Province No. 20ZD7FA003 National Natural Science Foundation of Gansu Province No. 25JRRA582 Project of Basic Scientific Research Business Expenses of Central Universities No. 561225004 Second Hospital of Lanzhou University Internal Talent Recruitment Program Fund No. yjrckyqdj-2024-02
Corresponding Author	Yu-Min Li, Chief Physician, MD, PhD, Professor, The Second Hospital and Clinical Medical School, Lanzhou University, No. 82 Cuiying Gate, Lanzhou 730000, Gansu Province, China. liym@lzu.edu.cn
Key Words	Gastric cancer; Metallomics; Trace element; Exposure; Metal-based therapies
Core Tip	Metallomics, a study of metallic elements in biological systems, is critical for understanding gastric cancer (GC). It helps identify biomarkers for early diagnosis and offers insights into treatment strategies. Novel biomarkers like matrix metalloproteinases, ferritin, and zinc (Zn2+) finger proteins can improve the sensitivity and accuracy of GC diagnosis compared to conventional tumor markers. Role of metals in GC: (1) Iron: Altered iron metabolism is linked to GC progression and can serve as a prognostic marker; (2) Copper: Copper imbalances contribute to GC development, and supplementation may enhance therapeutic effects; (3) Zn2+: Zn2+ stability is essential for cell function, and imbalances may indicate GC risk; and (4) Calcium: Abnormal calcium signal transduction may promote the occurrence, migration, invasion and other aspects of GC and affect prognosis. Metallomics faces challenges in identifying and quantifying metal-related biomarkers, dealing with low concentrations of elements, and overcoming issues with drug resistance. Advancements in analytical techniques and combining metal-based drugs with traditional therapies could improve GC diagnosis and treatment outcomes.
Citation	Jing LB, Liu J, Yang ZH, Yang FF, Wang DG, Li YM. Metallic elements and their molecular roles in gastric cancer: Pathogenic mechanisms and therapeutic implications. World J Gastrointest Oncol 2025; In press

Received	2025-09-17 06:43
Peer-Review Started	2025-09-17 06:43
First Decision by Editorial Office Director	2025-10-18 03:12
Return for Revision	2025-10-20 06:44
Revised	2025-11-03 06:41
Publication Fee Transferred
Second Decision by Editor	2025-12-01 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 10:53
Articles in Press	2025-12-02 10:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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