Publication Name	World Journal of Gastroenterology
Manuscript ID	114355
Country	Canada

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Clinical outcomes and drug sustainability after non-medical switch from ustekinumab originator to biosimilars in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Justin Kritzinger, Ivanna Candel, Gynter Kotrri, Huzaifa Nadeem, Waqqas Afif, Alain Bitton, Gary Wild, Talat Bessissow and Peter Laszlo Lakatos
Funding Agency and Grant Number
Corresponding Author	Peter Laszlo Lakatos, PhD, Professor, Division of Gastroenterology and Hepatology, McGill University, 1650 Avenue Cedar, Montreal H3A0G4, Quebec, Canada. kislakpet99@gmail.com
Key Words	Biosimilar; Inflammatory bowel disease; Ustekinumab; Efficacy; Drug sustainability
Core Tip	Switching from expensive originator biologics to lower-cost biosimilars can help reduce healthcare costs, but safety and effectiveness must be proven. This is the first real-world study of ustekinumab biosimilars in inflammatory bowel disease that showed stable disease control, unchanged biomarkers, and high treatment persistence, even in patients with prior biologic use and dose intensification. Fewer than 5% discontinued therapy, and no new safety issues emerged. These findings provide reassurance that biosimilars are a safe and effective alternative, supporting their wider adoption in clinical practice while ensuring patient outcomes remain uncompromised.
Citation	Kritzinger J, Candel I, Kotrri G, Nadeem H, Afif W, Bitton A, Wild G, Bessissow T, Lakatos PL. Clinical outcomes and drug sustainability after non-medical switch from ustekinumab originator to biosimilars in inflammatory bowel disease. World J Gastroenterol 2025; In press

Received	2025-09-17 07:45
Peer-Review Started	2025-09-17 07:51
To Make the First Decision
Return for Revision	2025-10-13 09:31
Revised	2025-10-15 02:33
Second Decision	2025-11-12 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 10:16
Articles in Press	2025-11-12 10:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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