Publication Name	World Journal of Stem Cells
Manuscript ID	114372
Country	Egypt

Category	Biology
Manuscript Type	Letter to the Editor
Article Title	Synergistic mesenchymal and neural stem cell therapy: Advancing neurorestoration in cerebral infarction
Manuscript Source	Invited Manuscript
All Author List	Noura A A Ebrahim, Moamen O Othman, Neveen S Tahoun, Thoraya A Farghaly and Soliman M A Soliman
Funding Agency and Grant Number
Corresponding Author	Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com
Key Words	Mesenchymal stem cells; Neural stem cells; Co-transplantation; Cerebral infarction; Stroke recovery; Angiogenesis; Neurotrophic factors; Regenerative medicine; Neurorestoration; Cell therapy
Core Tip	The combination of mesenchymal stem cells and neural stem cells offers a biologically synergistic strategy for stroke repair. Mesenchymal stem cells release angiogenic and immunomodulatory factors - such as vascular endothelial growth factor and platelet-derived growth factor - that promote vascular regeneration and temper inflammation, while neural stem cells directly replace lost neural cells and stimulate neuroplasticity. Recent clinical evidence indicates that co-transplantation not only improves functional outcomes but also elevates vascular endothelial growth factor and basic fibroblast growth factor levels, suggesting enhanced vascular remodeling and neural circuit repair. This “cell-cocktail” concept may represent a transformative approach to addressing the multifactorial nature of cerebral infarction and advancing precision regenerative medicine.
Citation	Ebrahim NAA, Othman MO, Tahoun NS, Farghaly TA, Soliman SMA. Synergistic mesenchymal and neural stem cell therapy: Advancing neurorestoration in cerebral infarction. World J Stem Cells 2025; In press

Received	2025-09-17 06:27
Peer-Review Started	2025-09-17 06:27
First Decision by Editorial Office Director	2025-10-10 07:45
Return for Revision	2025-10-10 07:45
Revised	2025-10-24 17:54
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 02:41
Articles in Press	2025-12-16 02:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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