| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Regional multi-center randomized trial of three vonoprazan-amoxicillin dosing regimens for Helicobacter pylori eradication in Sichuan Province, China
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chao-Qun Wu, Xiu Zhou, Chang-Ping Li, Qing-Ling He, Zong-Hua Chen, Shun-Bin Ding, Lei Deng, Lin-Lin Chen, Kai Jiang, Cheng-Kui Dong, Lian Hu, Guo-Bing Zhu, Cheng-Gang Zhang, Yan Zhang, Li-Li Wu, Wei Li, Yi-Hong Mao, Hua Zhang, Xia Ai, Yuan-Qing He, Yan Ma and Shuang-Yan He |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project Fund of the Health Commission of Sichuan Province |
19PJ290 |
|
| Corresponding Author |
Chang-Ping Li, Professor, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. 506854209@qq.com |
| Key Words |
Vonoprazan; Amoxicillin; Helicobacter pylori; Potassium-competitive acid blockers; Dose |
| Core Tip |
This multi-center randomized non-inferiority trial compared three vonoprazan (VPZ) plus amoxicillin (AMO) dual-therapy regimens: AMO 0.5 g QID, 0.75 g QID, and 1.0 g TID. All regimens achieved high eradication with excellent compliance and low adverse-event rates. The low-dose, high-frequency option (0.5 g QID) provided efficacy comparable to higher doses with superior tolerability, supporting dose optimization of VPZ-AMO as a practical first-line strategy in high-prevalence regions. |
| Citation |
Wu CQ, Zhou X, Li CP, He Ql, Chen ZH, Ding SB, Deng L, Chen LL, Jiang K, Dong CK, Hu L, Zhu GB, Zhang CG, Zhang Y, Wu LL, Li W, Mao YH, Zhang H, Ai X, He YQ, Ma Y, He SY. Regional multi-center randomized trial of three vonoprazan-amoxicillin dosing regimens for Helicobacter pylori eradication in Sichuan Province, China. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
