Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	114417
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Acupuncture regulating the gut-brain axis for postoperative ileus: Neuroimmune mechanisms and clinical translation prospects
Manuscript Source	Invited Manuscript
All Author List	De-Hui Li, Jia Yuan, Chang Qiao, Xiao-Tong Tian and Qian Yang
Funding Agency and Grant Number	Funding Agency Grant Number 2023 Government-Funded Project of the Outstanding Talents Training Program in Clinical Medicine ZF2023165 Key Research and Development Projects of Hebei Province 18277731D Natural Science Foundation of Hebei Province H2024423105 Hebei Provincial Administration of Traditional Chinese Medicine, Scientific Research Project 2023045, 2024023 Hebei Institute of Traditional Chinese Medicine Pharmaceutical Preparation Industry Technology Special Project YJY2024006 Scientific Research Project of Health Commission of Hebei Province 20220962, 20240282
Corresponding Author	Qian Yang, Chief Physician, Professor, Hebei Key Laboratory of Turbidity Toxin Syndrome, Department of Gastroenterology, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), No. 389 Zhongshan East Road, Shijiazhuang 050011, Hebei Province, China. yang0311qian@126.com
Key Words	Clinical translation; Neuroimmunity; Postoperative ileus; Gut-brain axis; Acupuncture
Core Tip	Based on emerging evidence for electroacupuncture at Zusanli (ST36) in treating postoperative ileus via the vagus nerve-mediated anti-inflammatory pathway, this article systematically details the mechanisms by which acupuncture regulates gastrointestinal motility through neural, immune, endocrine, and microbial pathways. It provides a strong rationale for integrating acupuncture, an effective non-pharmacological therapy, into enhanced recovery after surgery protocols. Future research focusing on multi-omics technologies, large-scale clinical trials, and microbiota-gut-brain interactions will be crucial for advancing the clinical application of acupuncture in gastrointestinal motility disorders.
Citation	Li DH, Yuan J, Qiao C, Tian XT, Yang Q. Acupuncture regulating the gut-brain axis for postoperative ileus: Neuroimmune mechanisms and clinical translation prospects. World J Gastrointest Surg 2025; In press

Received	2025-09-27 17:13
Peer-Review Started	2025-09-27 17:13
To Make the First Decision
Return for Revision	2025-10-10 03:02
Revised	2025-10-24 05:41
Second Decision	2025-11-27 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 06:36
Articles in Press	2025-11-27 06:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com