Publication Name	World Journal of Clinical Oncology
Manuscript ID	114423
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Immunosuppressive tumor microenvironment shape pancreatic cancer unresponsive to current immunotherapies
Manuscript Source	Invited Manuscript
All Author List	Zong-Yang Li, Si-Yu Peng, Fei-Long Li and Hong-Qiao Cai
Funding Agency and Grant Number
Corresponding Author	Hong-Qiao Cai, Associate Professor, MD, PhD, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. hongqiaocai@jlu.edu.cn
Key Words	Pancreatic ductal adenocarcinoma; Immunosuppressive tumor microenvironment; Regulatory T cells; Myeloid-derived suppressor cells; Tumor-associated macrophages
Core Tip	Pancreatic ductal adenocarcinoma is characterized by a highly immunosuppressive tumor microenvironment dominated by regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages. These cells form a synergistic network that promotes immune evasion and resistance to immunotherapy. Recent advances in single-cell transcriptomics have revealed cellular heterogeneity and identified novel therapeutic targets. Emerging strategies focus on depleting or reprogramming these immunosuppressive populations, often in combination with checkpoint blockade or chemotherapy. A multi-target approach is essential to convert pancreatic ductal adenocarcinoma from an immunologically “cold” to “hot” tumor and improve patient outcomes.
Citation	Li ZY, Peng SY, Li FL, Cai HQ. Immunosuppressive tumor microenvironment shape pancreatic cancer unresponsive to current immunotherapies. World J Clin Oncol 2025; In press

Received	2025-09-19 08:12
Peer-Review Started	2025-09-19 08:12
First Decision by Editorial Office Director	2025-09-25 09:07
Return for Revision	2025-09-25 09:07
Revised	2025-09-28 08:31
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 09:15
Articles in Press	2025-12-15 09:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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