Publication Name	World Journal of Stem Cells
Manuscript ID	114433
Country	China

Category	Neurosciences
Manuscript Type	Letter to the Editor
Article Title	Synergistic potential of combined neural stem cells and mesenchymal stem cells therapy in acute cerebral infarction: A perspective
Manuscript Source	Invited Manuscript
All Author List	Jing-Yu Li, Shu-Zhen Liu, Xin-Yi Xu and Lan Zhao
Funding Agency and Grant Number
Corresponding Author	Lan Zhao, PhD, Professor, /, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. lanzhao69@163.com
Key Words	Mesenchymal stem cells; Neural stem cells; Acute cerebral infarction; Growth factors; Cell transplantation
Core Tip	We note a recently published randomized controlled trial investigating the efficacy and mechanisms of combined mesenchymal and neural stem cell therapy for acute cerebral infarction. The study systematically validated, at the clinical level, the therapy’s role in promoting neurological recovery through the regulation of vascular endothelial growth factor and basic fibroblast growth factor, while demonstrating a favorable safety profile. In this letter, we share our perspectives.
Citation	Li JY, Liu SZ, Xu XY, Zhao L. Synergistic potential of combined neural stem cells and mesenchymal stem cells therapy in acute cerebral infarction: A perspective. World J Stem Cells 2026; In press

Received	2025-09-19 08:03
Peer-Review Started	2025-09-19 08:03
First Decision by Editorial Office Director	2025-11-18 07:35
Return for Revision	2025-11-18 07:35
Revised	2025-11-30 03:39
Publication Fee Transferred
Second Decision by Editor	2026-01-12 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 12:50
Articles in Press	2026-01-12 12:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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