Publication Name	World Journal of Psychiatry
Manuscript ID	114446
Country	China

Category	Psychiatry
Manuscript Type	Randomized Controlled Trial
Article Title	Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depression through immune-inflammatory modulation: An extended trial analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Du-Xing Li, Yi Gu, Wen-Juan Xia, Yi-Fan Sun, Lu Hou, Wen-Xian Zhu and Jun Wang
Funding Agency and Grant Number	Funding Agency Grant Number the Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee No. BJ2023086 Wuxi Taihu Talent Project No. WXTTP 2021
Corresponding Author	Jun Wang, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, No. 156 Qianrong Road, Binhu District, Wuxi 214151, Jiangsu Province, China. woodfish2@126.com
Key Words	Anhedonia; Major depressive disorder; Probiotics; Inflammatory markers; Event-related potentials
Core Tip	This study investigated whether Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depressive disorder through immune-inflammatory modulation and reward-related electrophysiological changes. The probiotic significantly reduced inflammatory markers (lipopolysaccharide, C-reactive protein, and interleukin-6) and enhanced reward anticipation, as reflected by increased stimulus-preceding negativity amplitude and higher Temporal Experience of Pleasure Scale scores. These results suggest that CCFM6432 may improve anhedonia via an immune-inflammatory pathway. Large-scale, multicenter studies integrating multimodal biomarkers are warranted to validate and extend these findings.
Citation	Li DX, Gu Y, Xia WJ, Sun YF, Hou L, Zhu WX, Wang J. Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depression through immune-inflammatory modulation: An extended trial analysis. World J Psychiatry 2025; In press

Received	2025-09-19 11:33
Peer-Review Started	2025-09-19 11:34
First Decision by Editorial Office Director	2025-10-24 10:56
Return for Revision	2025-10-24 10:56
Revised	2025-11-06 13:04
Publication Fee Transferred	2025-11-12 11:10
Second Decision by Editor	2025-12-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-09 08:50
Articles in Press	2025-12-09 08:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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