Publication Name	World Journal of Gastroenterology
Manuscript ID	114468
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Rhapontin activating nuclear factor erythroid 2-related factor 2 to ameliorate Parkinson’s disease-associated gastrointestinal dysfunction
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Xiao Chen, Na-Qi Sun and Sai-Jun Mo
Funding Agency and Grant Number
Corresponding Author	Sai-Jun Mo, Associate Professor, PhD, Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhongyuan District, Zhengzhou 450001, Henan Province, China. sjmo@zzu.edu.cn
Key Words	Rhapontin; Gastrointestinal dysfunction; Parkinson’s disease; Nuclear factor erythroid 2-related factor 2; Anti-inflammatory
Core Tip	This commentary argues that realizing rhapontin’s potential in ameliorating Parkinson’s disease (PD)-associated gastrointestinal dysfunction requires a systems-level understanding of its interaction with the gut microbiota and signaling networks beyond nuclear factor erythroid 2-related factor 2 (NRF2) (e.g., nuclear factor kappa-B, adenosine monophosphate-activated protein kinase, sirtuin 1). It emphasizes that rhapontin’s colonic NRF2-mediated local anti-inflammatory effects support PD’s “enteric pathology hypothesis” and highlight colonic NRF2 as a priority intervention target.
Citation	Chen YX, Sun NQ, Mo SJ. Rhapontin activating nuclear factor erythroid 2-related factor 2 to ameliorate Parkinson’s disease-associated gastrointestinal dysfunction. World J Gastroenterol 2025; In press

Received	2025-09-22 03:04
Peer-Review Started	2025-09-22 03:04
First Decision by Editorial Office Director	2025-11-14 09:14
Return for Revision	2025-11-14 09:14
Revised	2025-11-16 05:24
Publication Fee Transferred
Second Decision by Editor	2025-12-26 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-26 08:14
Articles in Press	2025-12-26 08:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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