Publication Name	World Journal of Gastroenterology
Manuscript ID	114479
Country	China

Category	Microbiology
Manuscript Type	Review
Article Title	Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Fan Song, Yi Liu, Qiao-Man Fei, Chun-Lan Xu and Fan-Pu Ji
Funding Agency and Grant Number	Funding Agency Grant Number Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University No. CX2023021
Corresponding Author	Fan-Pu Ji, Department of Hepatology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an 710004, Shaanxi Province, China. jifanpu1979@163.com
Key Words	Gut microbiota; Hypertriglyceridemia; Gut-pancreas axis; Acute pancreatitis; Microbial-host-isozyme
Core Tip	Current academic consensus is that hypertriglyceridemia (HTG) primarily exacerbates acute pancreatitis (AP) through lipotoxicity. This traditional view emphasizes that in HTG, pancreatic lipase in acinar cells hydrolyzes triglycerides, generating excessive free fatty acids, which exacerbates AP severity. However, recent evidence has increasingly demonstrated the critical role of the gut microbiota in this pathological process. This review explores how gut microbiota dysbiosis mediates the aggravation of AP caused by HTG, focusing on mechanisms such as microbial translocation, immune dysregulation, and metabolites. The novel “microbial-host-isozyme” concept is proposed for precise diagnosis and therapy in HTG-AP.
Citation	Song XF, Liu Y, Fei QM, Xu CL, Ji FP. Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis. World J Gastroenterol 2025; In press

Received	2025-09-22 03:22
Peer-Review Started	2025-09-22 03:23
To Make the First Decision
Return for Revision	2025-10-28 10:02
Revised	2025-11-08 16:03
Second Decision	2025-11-18 01:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 09:31
Articles in Press	2025-11-18 09:31
Publication Fee Transferred	2025-11-10 14:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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