Publication Name	World Journal of Hepatology
Manuscript ID	114481
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Assessing the associations between immunosuppressant use and COVID-19 severity in patients with autoimmune hepatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Krish Rai, Karla J Lindquist, John Kornak and Jin Ge
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Diabetes and Digestive and Kidney Diseases K23DK139455 UCSF Liver Center Grant 5P30DK026743-43
Corresponding Author	Jin Ge, Assistant Professor, MD, Department of Medicine, University of California, 513 Parnassus Avenue, S-357, San Francisco, CA 94143, United States. jin.ge@ucsf.edu
Key Words	Autoimmune hepatitis; COVID-19; Immunosuppressants; Chronic liver disease; Model for end stage liver disease 3.0 score
Core Tip	The effect of immunosuppressive medications on coronavirus disease 2019 (COVID-19) outcomes, including for patients with autoimmune hepatitis (AIH), has been variable across research studies. To address these uncertainties, we utilized data from the National Clinical Cohort Collaborative COVID enclave, a national COVID-19 multi-center electronic health record database to determine the influence of immunosuppressive therapy on testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and clinical outcomes in AIH patients. In this study of 15187 patients with AIH, we found a negative association between prednisone use and SARS-CoV-2 infection, while interactions between prednisone and tacrolimus and budesonide and azathioprine had a positive association with SARS-CoV-2 infection.
Citation	Rai K, Lindquist KJ, Kornak J, Ge J. Assessing the associations between immunosuppressant use and COVID-19 severity in patients with autoimmune hepatitis. World J Hepatol 2025; In press

Received	2025-09-22 05:19
Peer-Review Started	2025-09-22 05:19
First Decision by Editorial Office Director	2025-09-29 07:31
Return for Revision	2025-09-29 07:31
Revised	2025-10-13 21:49
Publication Fee Transferred	2025-10-30 03:43
Second Decision by Editor	2025-12-16 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 08:51
Articles in Press	2025-12-16 08:51
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Typeset the Manuscript

ISSN	1948-5182 (online)
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