Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	114502
Country	India

Category	Pathology
Manuscript Type	Editorial
Article Title	Molecular mosaic of colorectal cancer: Why one classification system is no longer enough?
Manuscript Source	Invited Manuscript
All Author List	Sunita Ahlawat and Sumanta Das
Funding Agency and Grant Number
Corresponding Author	Sumanta Das, Department of Pathology, Agilus Diagnostics Ltd, Fortis Memorial Research Institute, Sector 44, Opposite Huda City Centre, Gurugram 122002, Haryana, India. sumantad755@gmail.com
Key Words	Consensus molecular subtypes; Heterogeneity; Colorectal cancer intrinsic subtypes; Pathway-derived subtypes; Clinical translation
Core Tip	Colorectal cancer (CRC) is not a single disease but a molecular mosaic. The consensus molecular subtypes brought important progress, yet nearly a decade of experience highlights its limitations - heterogeneity, unclassified cases, and bulk transcriptomic biases. Emerging systems such as CRC intrinsic subtypes, pathway-derived subtypes, and stem cell-based frameworks reveal complementary biological perspectives. Precision oncology for CRC requires abandoning the search for one “best” classification and instead embracing a pluralistic, multi-omic, and adaptive taxonomy that aligns with distinct clinical needs.
Citation	Ahlawat S, Das S. Molecular mosaic of colorectal cancer: Why one classification system is no longer enough? World J Gastrointest Oncol 2025; In press

Received	2025-09-22 02:47
Peer-Review Started	2025-09-22 02:48
To Make the First Decision
Return for Revision	2025-10-21 06:24
Revised	2025-11-03 18:52
Second Decision	2025-11-27 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 06:19
Articles in Press	2025-11-27 06:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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