Publication Name	World Journal of Gastroenterology
Manuscript ID	114538
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Noninvasive diagnosis of colorectal adenoma: The emerging potential of blood-based biomarkers
Manuscript Source	Unsolicited Manuscript
All Author List	Cen-Yi Qi, Ran Wang, Jia-Wei Wang, Guo-Liang Ye, Ping Yang and Yu-Ping Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Ningbo “Kechuang Yongjiang 2035” Major RD Program No. 2025Z150 Zhejiang Provincial Natural Science Foundation of China No. LBY23H200006 Traditional Chinese Medicine Science and Technology Program of Zhejiang Province No. 2025ZL115
Corresponding Author	Yu-Ping Zhou, PhD, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Ningbo University, No. 247 Renmin Road, Jiangbei District, Ningbo 315020, Zhejiang Province, China. fyzhouyuping@nbu.edu.cn
Key Words	Advanced adenoma; Colorectal adenoma; Circulating biomarkers; Noninvasive screening; Early detection; Colorectal cancer
Core Tip	Most colorectal cancers arise from adenomas, particularly advanced adenomas. Blood-based biomarkers identified through multiomics approaches, including proteomics, metabolomics, transcriptomics, and epigenomics, offer a promising noninvasive strategy to enhance the sensitivity and specificity of adenoma detection and colorectal cancer risk assessment.
Citation	Qi CY, Wang R, Wang JW, Ye GL, Yang P, Zhou YP. Noninvasive diagnosis of colorectal adenoma: The emerging potential of blood-based biomarkers. World J Gastroenterol 2025; In press

Received	2025-09-23 06:41
Peer-Review Started	2025-09-23 06:41
First Decision by Editorial Office Director	2025-11-18 10:49
Return for Revision	2025-11-18 10:49
Revised	2025-12-01 01:45
Publication Fee Transferred	2025-12-05 02:05
Second Decision by Editor	2025-12-29 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-29 05:51
Articles in Press	2025-12-29 05:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com