Publication Name	World Journal of Gastroenterology
Manuscript ID	114544
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Lianhe Xiaozhi ointment ameliorates metabolic dysfunction-associated steatotic liver disease via peroxisome proliferator-activated receptor alpha pathway activation
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Juan Nie, Gao-Xiang Wang, Xin-Yi Yang, Jing Sun, Yu-Tian Cao, Yan Lou, Yi-Fan Lu, Jiang-Yi Yu and Xi-Qiao Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82474318 Jiangsu Administration of Traditional Chinese Medicine No. QN202411 Special Fund for Training Outstanding Young Doctors in the Second Session of Jiangsu Province Hospital of Chinese Medicine No. 2024QB002
Corresponding Author	Xi-Qiao Zhou, Director, PhD, Professor, Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Qinhuai District, Nanjing 210029, Jiangsu Province, China. zhouxiqiao@njucm.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Traditional Chinese medicine; Peroxisome proliferator-activated receptor alpha; Inflammation; Network pharmacology
Core Tip	Lianhe Xiaozhi ointment effectively alleviates metabolic dysfunction-associated steatotic liver disease by improving glucolipid metabolism, reducing liver injury and inflammation, and modulating gut microbiota. Its therapeutic effect is primarily mediated via activation of peroxisome proliferator-activated receptor alpha signaling. These insights provide a theoretical foundation for the clinical application of Lianhe Xiaozhi ointment.
Citation	Nie LJ, Wang GX, Yang XY, Sun J, Cao YT, Lou Y, Lu YF, Yu JY, Zhou XQ. Lianhe Xiaozhi ointment ameliorates metabolic dysfunction-associated steatotic liver disease via peroxisome proliferator-activated receptor alpha pathway activation. World J Gastroenterol 2025; In press

Received	2025-09-30 03:07
Peer-Review Started	2025-09-30 03:07
First Decision by Editorial Office Director	2025-10-27 09:52
Return for Revision	2025-10-27 09:52
Revised	2025-11-06 04:02
Publication Fee Transferred	2025-11-10 09:05
Second Decision by Editor	2025-12-25 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 09:42
Articles in Press	2025-12-25 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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