Publication Name	World Journal of Psychiatry
Manuscript ID	114553
Country	China

Category	Neurosciences
Manuscript Type	Basic Study
Article Title	Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Zhong, Wei Chen, Sen Li, Dong-Lin Zheng, Yi-Dan Wang, Jia-Hui Huang, Xing-Qiu Liang and Ming-Kun Liang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation No. 81960807 Guangxi Natural Science Foundation No. 2023GXNSFAA026237 Guangxi Xinglin Young Talents Project of Guangxi University of Traditional Chinese medicine No. 2022C026 and No. 2022C042 Guangxi Zhuang Autonomous Region’s First Batch of Medical Young Reserve Talent Training Program
Corresponding Author	Xing-Qiu Liang, PhD, Department of Science and Technology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 530011, Guangxi Zhuang Autonomous Region, China. 121308213@qq.com
Key Words	Guipi pill; Depression; Gut-brain axis; Traditional Chinese medicine; Immune regulation; Transcriptomics; Granzyme A; Chronic unpredictable mild stress; Inflammatory bowel disease; Expression quantitative trait loci
Core Tip	This study demonstrates that the traditional formula Guipi pill (GPP) alleviates depression by modulating the gut-brain axis via immune regulation. GPP significantly improved depressive-like behaviors in a chronic unpredictable mild stress rat model and altered the expression of 1349 genes, with GZMA playing a key role. Mechanistically, GPP enhanced GZMA expression in CD8+ T-cell subsets, promoting effector T cells while reducing naïve T cells. These results suggest a novel immune-mediated pathway for GPP’s antidepressant effect.
Citation	Zhong J, Chen W, Li S, Zheng DL, Wang YD, Huang JH, Liang XQ, Liang MK. Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation. World J Psychiatry 2026; In press

Received	2025-09-23 07:43
Peer-Review Started	2025-09-23 07:44
First Decision by Editorial Office Director	2025-10-24 11:13
Return for Revision	2025-10-26 14:47
Revised	2025-11-14 16:03
Publication Fee Transferred	2025-11-18 08:03
Second Decision by Editor	2026-02-02 02:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-02 05:43
Articles in Press	2026-02-02 05:43
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ISSN	2220-3206 (online)
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