Publication Name	World Journal of Gastroenterology
Manuscript ID	114560
Country	Portugal

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease?
Manuscript Source	Invited Manuscript
All Author List	Kalinne Kelly Lima Gadelha, Armênio Aguiar Santos, Paulo Correia-de-Sá, Pedro Jorge Caldas Magalhães and Moisés Tolentino Bento da Silva
Funding Agency and Grant Number
Corresponding Author	Moisés Tolentino Bento da Silva, Assistant Professor, Laboratory of Physiology, Department of Immuno-Physiology and Pharmacology, School of Medicine and Biomedical Science, Center for Drug Discovery and Innovative Medicines/RISE-Health: Health Research Network, University of Porto, No. 228 Jorge Viterbo Ferreira Street, Porto 4050-313, Portugal. mtsilva@icbas.up.pt
Key Words	Gastroesophageal reflux disease; Oesophageal motility; Bile acids and salts; Barrett’s oesophagus; G-protein-coupled bile acid receptor
Core Tip	Gastroesophageal reflux disease is characterised by the retrograde flow of gastroduodenal contents into the oesophagus. Although its pathophysiology is not fully understood, it is recognised to evolve into different forms of varying severity, including Barrett’s oesophagus and oesophageal adenocarcinoma. Impaired oesophageal motility, often characterised as hypomotility, is a primary factor contributing to the disease’s development. Studies suggest that the liver-synthesized bile salts, which are duodenal components found in the reflux material, may be directly involved in this dysfunction. Therefore, more in-depth investigations are needed to fully understand gastroesophageal reflux disease’s pathophysiology and the influence of bile salts on oesophageal dysmotility, as well as potential signalling pathways.
Citation	Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB. Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? World J Gastroenterol 2025; In press

Received	2025-09-23 05:59
Peer-Review Started	2025-09-23 06:00
First Decision by Editorial Office Director	2025-10-23 08:58
Return for Revision	2025-10-23 08:58
Revised	2025-11-04 22:35
Publication Fee Transferred
Second Decision by Editor	2025-12-02 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-03 04:01
Articles in Press	2025-12-03 04:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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