Publication Name	World Journal of Gastroenterology
Manuscript ID	114563
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Isolated colonic aspergillosis in an immunocompetent individual diagnosed by metagenomic next-generation sequencing: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Guo, Xian Wang, Shao-Yang Wang and Tao-Fa Lin
Funding Agency and Grant Number	Funding Agency Grant Number Subproject of National Key Research and Development Program of China 2022YFC2305001
Corresponding Author	Tao-Fa Lin, Academic Fellow, Department of Infections, The 900th Hospital of PLA Joint Logistic Support Force, No. 156 West Second Ring North Road, Gulou District, Fuzhou 350025, Fujian Province, China. ltfa2016@qq.com
Key Words	Invasive aspergillosis; Primary intestinal aspergillosis; Immunocompetent individual; Voriconazole; Metagenomic next-generation sequencing; Case report
Core Tip	This case report describes an unusual presentation of refractory diarrhea in a patient who was immunocompetent and had none of the usual risk factors. Despite comprehensive evaluations including endoscopy and histopathology, the etiology remained undetermined. Metagenomic next-generation sequencing (mNGS) identified Aspergillus fumigatus, guiding successful targeted treatment. This highlights the necessity of considering primary intestinal aspergillosis (PA) in certain patients and demonstrates the diagnostic value of mNGS for rare fungal enteritis. Although publication bias may exist, accumulating case reports support considering PA when diagnosing unexplained diarrhea. Furthermore, the use of mNGS is justified when conventional diagnostic methods are inconclusive.
Citation	Guo T, Wang X, Wang SY, Lin TF. Isolated colonic aspergillosis in an immunocompetent individual diagnosed by metagenomic next-generation sequencing: A case report. World J Gastroenterol 2026; In press

Received	2025-09-24 02:31
Peer-Review Started	2025-09-24 02:31
First Decision by Editorial Office Director	2025-10-31 09:16
Return for Revision	2025-10-31 09:16
Revised	2025-11-14 12:42
Publication Fee Transferred	2025-11-20 11:31
Second Decision by Editor	2026-02-02 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-02 14:23
Articles in Press	2026-02-02 14:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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