Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	114569
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Adjuvant irinotecan-apatinib therapy for recurrent/metastatic gastric cancer after surgery: A real-world evaluation
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Feng Shi, Hui Xu, Jin-Feng Gao and Jian-Bin Wu
Funding Agency and Grant Number
Corresponding Author	Jian-Bin Wu, MD, Department of Human Resources, Jiangsu Hengrui Medicine Co.,Ltd, No. 1288 Haike Road, Shanghai 200122, China. 18205137866@163.com
Key Words	Real-world evidence; Irinotecan; Apatinib; Postoperative recurrence; Metastatic gastric cancer
Core Tip	This study presents a real-world data analysis of clinical efficacy outcomes associated with irinotecan-apatinib adjuvant therapy among patients with postoperative recurrent/metastatic gastric cancer (RMGC). We included 124 postsurgical RMGC patients treated from April 2021 to April 2024, all of whom received the S-1 (via intravenous infusion) plus oxaliplatin (via oral administration; S-1+oxaliplatin) regimen. The irinotecan-apatinib adjuvant therapy for these patients demonstrated significant clinical advantages in inhibiting inflammation and serum tumor markers while improving quality of life, which could be a better option for these patients.
Citation	Shi JF, Xu H, Gao JF, Wu JB. Adjuvant irinotecan-apatinib therapy for recurrent/metastatic gastric cancer after surgery: A real-world evaluation. World J Gastrointest Surg 2026; In press

Received	2025-11-18 09:23
Peer-Review Started	2025-11-18 09:23
First Decision by Editorial Office Director	2025-12-09 06:54
Return for Revision	2025-12-09 06:54
Revised	2025-12-22 13:30
Publication Fee Transferred
Second Decision by Editor	2026-01-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 09:45
Articles in Press	2026-01-12 09:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com