Publication Name	World Journal of Diabetes
Manuscript ID	114603
Country	Italy

Category	Ophthalmology
Manuscript Type	Review
Article Title	Beyond glycemia: The influence of systemic inflammation, lipids, and the gut-retina axis in diabetic retinopathy
Manuscript Source	Invited Manuscript
All Author List	Marco Zeppieri, Alessandro Drigo, Matteo Capobianco, Federico Visalli, Francesco Cappellani, Mutali Musa, Rosa Giglio, Daniele Tognetto, Marieme Khouyyi, Caterina Gagliano, Fabiana D’Esposito and Leandro Inferrera
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, Consultant, MD, PhD, Department of Ophthalmology, University Hospital of Udine, Piazza Santa Maria della Misericordia, 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Systemic inflammation; Gut-retina axis; Dyslipidemia; Diabetic retinopathy; Metabolic memory
Core Tip	Diabetic retinopathy is becoming recognized as a systemic condition affected not just by chronic hyperglycemia but also by ongoing inflammation, lipid dysregulation, and abnormalities in the gut flora. These interrelated pathways lead to retinal vascular impairment, neurodegeneration, and disease advancement. Identifying these characteristics provides a comprehensive framework for understanding disease pathophysiology and discovering novel therapeutic targets that extend beyond glycemic control.
Citation	Zeppieri M, Drigo A, Capobianco M, Visalli F, Cappellani F, Musa M, Giglio R, Tognetto D, Khouyyi M, Gagliano C, D’Esposito F, Inferrera L. Beyond glycemia: The influence of systemic inflammation, lipids, and the gut-retina axis in diabetic retinopathy. World J Diabetes 2025; In press

Received	2025-09-24 01:25
Peer-Review Started	2025-09-25 05:45
First Decision by Editorial Office Director	2025-10-11 03:05
Return for Revision	2025-10-11 03:05
Revised	2025-10-20 10:32
Publication Fee Transferred
Second Decision by Editor	2025-12-09 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 10:54
Articles in Press	2025-12-17 10:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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