Publication Name	World Journal of Diabetes
Manuscript ID	114624
Country	South Korea

Category	Medicine, General & Internal
Manuscript Type	Case Control Study
Article Title	Combined effects of glycemic status and adiposity on cardiovascular risk in chronic kidney disease: A nationwide population-based study
Manuscript Source	Unsolicited Manuscript
All Author List	Eun Hui Bae, Sang Yup Lim, Bong Seong Kim, Kyungdo Han, Sang Heon Suh, Hong Sang Choi, Eun Mi Yang, Chang Seong Kim, Seong Kwon Ma and Soo Wan Kim
Funding Agency and Grant Number	Funding Agency Grant Number the National Research Foundation of Korea (NRF) Grant Funded by the Korean Government (MSIT) RS-2023-00217317
Corresponding Author	Soo Wan Kim, MD, PhD, Professor, Department of Internal Medicine, Chonnam National University Medical School, Jebongro 42, Gwangju 61469, South Korea. skimw@chonnam.ac.kr
Key Words	Chronic kidney disease; Cardiovascular disease; Diabetes mellitus; Waist circumference; Body mass index; Obesity
Core Tip	This nationwide cohort study of over 1.7 million individuals with chronic kidney disease (CKD) demonstrates that cardiovascular (CV) risk is strongly modified by both glycemic status and patterns of adiposity. Diabetes consistently amplified CV risk across all body mass index and waist circumference categories, negating any protective effect of higher adiposity. Conversely, underweight and centrally lean individuals with diabetes exhibited the greatest vulnerability, underscoring that leanness is not universally protective in CKD. These findings highlight the importance of integrating both glycemic status and obesity indices into individualized CV risk assessment and prevention strategies for patients with CKD.
Citation	Bae EH, Lim SY, Kim BS, Han K, Suh SH, Choi HS, Yang EM, Kim CS, Ma SK, Kim SW. Combined effects of glycemic status and adiposity on cardiovascular risk in chronic kidney disease: A nationwide population-based study. World J Diabetes 2025; In press

Received	2025-09-24 01:30
Peer-Review Started	2025-09-29 08:08
To Make the First Decision
Return for Revision	2025-10-23 08:15
Revised	2025-10-27 22:45
Second Decision	2025-11-20 02:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 05:15
Articles in Press	2025-11-27 05:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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