Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	114634
Country	China

Category	Oncology
Manuscript Type	Editorial
Article Title	Systemic immune-inflammation index and serum lactoferrin: A novel tool for individualized prognostic assessment in elderly colon cancer
Manuscript Source	Invited Manuscript
All Author List	Shu-Qi Ren, Zhuo-Ling Huang, Zu-Xun Qiu and Chuang Cai
Funding Agency and Grant Number
Corresponding Author	Chuang Cai, Assistant Professor, PhD, Cancer Research Institute of Zhongshan City, Zhongshan City People's Hospital, No. 2 Sunwen East Road, Zhongshan 528445, Guangdong Province, China. caich6@foxmail.com
Key Words	Systemic immune-inflammation index; Serum lactoferrin; Colon cancer; Elder; Prognosis
Core Tip	This prospective study identifies elevated preoperative systemic immune-inflammation index combined with low serum lactoferrin as independent prognostic biomarkers in elderly colon cancer patients. This cost-effective and easily measurable combination reflects both systemic inflammatory burden and immune-nutritional status, enhancing traditional tumor node metastasis staging. It holds substantial potential for individualized postoperative risk stratification in routine clinical practice.
Citation	Ren SQ, Huang ZL, Qiu ZX, Cai C. Systemic immune-inflammation index and serum lactoferrin: A novel tool for individualized prognostic assessment in elderly colon cancer. World J Gastrointest Surg 2025; In press

Received	2025-09-24 09:32
Peer-Review Started	2025-09-24 09:32
First Decision by Editorial Office Director	2025-12-02 07:23
Return for Revision	2025-12-02 07:23
Revised	2025-12-15 12:34
Publication Fee Transferred
Second Decision by Editor	2025-12-26 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-26 05:59
Articles in Press	2025-12-26 05:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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