Publication Name	World Journal of Gastroenterology
Manuscript ID	114677
Country	Taiwan

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Role of leucine-rich α-2-glycoprotein in Taiwanese patients with inflammatory bowel disease as a predictive biomarker for endoscopic activity
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Chu Chen, Meng-Tzu Weng, Feng-Pai Tsai, Zhi-Che Chen, Hsin-Yun Wu, Chien-Chih Tung, Chun-Ying Wang and Shu-Chen Wei
Funding Agency and Grant Number	Funding Agency Grant Number National Science and Technology Council of Taiwan MOST 111-2314-B-002-188-MY3 Liver Disease Prevention and Treatment Research Foundation
Corresponding Author	Shu-Chen Wei, MD, PhD, Professor, Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chungshan South Road, Taipei 100, Taiwan. shuchenwei@ntu.edu.tw
Key Words	Leucine-rich α-2-glycoprotein; Ulcerative colitis; Crohn’s disease; Inflammatory bowel disease; Biomarkers
Core Tip	Endoscopy and fecal calprotectin (FC) are standard tools for examining disease activity in inflammatory bowel disease (IBD) but both have limitations. We evaluated serum leucine-rich α-2-glycoprotein (LRG) as a noninvasive biomarker in a Taiwanese IBD cohort. LRG correlated with FC, C-reactive protein (CRP), hemoglobin, and albumin. In ulcerative colitis, LRG predicted endoscopic activity, particularly in patients with normal CRP levels. Combining CRP, hemoglobin, and LRG significantly improved the endoscopic activity prediction to nearly that of FC. Our findings support the clinical utility of LRG as a complementary biomarker for disease monitoring in IBD, particularly in ulcerative colitis with low CRP.
Citation	Chen YC, Weng MT, Tsai FP, Chen ZC, Wu HY, Tung CC, Wang CY, Wei SC. Role of leucine-rich α-2-glycoprotein in Taiwanese patients with inflammatory bowel disease as a predictive biomarker for endoscopic activity. World J Gastroenterol 2025; In press

Received	2025-09-26 09:39
Peer-Review Started	2025-09-26 09:39
First Decision by Editorial Office Director	2025-10-11 09:07
Return for Revision	2025-10-11 09:07
Revised	2025-10-24 16:29
Publication Fee Transferred	2025-10-29 04:47
Second Decision by Editor	2025-12-01 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 09:51
Articles in Press	2025-12-02 09:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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