Publication Name	World Journal of Cardiology
Manuscript ID	114706
Country	Greece

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Letter to the Editor
Article Title	Frailty first: Rethinking invasive strategies for elderly patients with non-ST-elevation myocardial infarction
Manuscript Source	Invited Manuscript
All Author List	Nikias Milaras, Konstantinos Toutouzas and Skevos Sideris
Funding Agency and Grant Number
Corresponding Author	Nikias Milaras, Department of Cardiology, "Hippokration" General Hospital, Athens 11527, Greece. nikiasmilaras@gmail.com
Key Words	Percutaneous coronary intervention; Cardiac catheterization; Frailty; Non-ST-elevation myocardial infarction
Core Tip	Frailty influences outcomes in elderly patients with non-ST-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI). In a large United States cohort, PCI reduced in-hospital mortality across all frailty levels, yet benefits declined and complications, length of stay, and costs rose with increasing frailty. These findings highlight that frailty should not preclude PCI but must be routinely assessed to guide individualized decision-making, risk prediction, and resource allocation in acute coronary care.
Citation	Milaras N, Toutouzas K, Sideris S. Frailty first: Rethinking invasive strategies for elderly patients with non-ST-elevation myocardial infarction. World J Cardiol 2025; In press

Received	2025-09-26 08:24
Peer-Review Started	2025-09-26 08:26
First Decision by Editorial Office Director	2025-10-29 09:21
Return for Revision	2025-10-29 09:21
Revised	2025-11-02 18:48
Publication Fee Transferred
Second Decision by Editor	2025-12-24 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-24 07:35
Articles in Press	2025-12-24 07:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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