Publication Name	World Journal of Psychiatry
Manuscript ID	114719
Country	China

Category	Neuroimaging
Manuscript Type	Observational Study
Article Title	Significance of arterial spin labeling in relation to sertraline treatment response in adolescents with major depressive disorder
Manuscript Source	Invited Manuscript
All Author List	Xiao Liu, Chuan Liu, Yun-Zhen Pu, Dan Liu, Hong-Sheng Liu, Dan-Feng Xiang, Xiao-Yue Zhang, Xing-Yu Wang, Qian-Xi Yang, Rui Jin and Ren-Qiang Yu
Funding Agency and Grant Number	Funding Agency Grant Number The “Medicine + X” Program of Chongqing Translational Medicine Center No. Y+X202409
Corresponding Author	Ren-Qiang Yu, Assistant Professor, PhD, Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. yurenqiang@hospital.cqmu.edu.cn
Key Words	Adolescent depression; Functional magnetic resonance imaging; Major depressive disorder; Cerebral blood flow; Arterial spin labeling
Core Tip	Adolescent major depressive disorder is a global concern with limited treatment efficacy. This study used arterial spin labeling magnetic resonance imaging to evaluate cerebral blood flow changes during sertraline treatment and to examine whether baseline perfusion was associated with subsequent response. Thirty-three adolescents with adolescent major depressive disorder were assessed before and after eight weeks of treatment. A significant reduction in depressive symptoms was observed over eight weeks, and responders showed higher baseline cerebral blood flow in the right insula. These exploratory findings suggest that insular perfusion may index treatment-relevant states, but do not establish causality or predictive utility; confirmation in randomized, placebo or psychotherapy-controlled trials is required before informing clinical decision-making.
Citation	Liu X, Liu C, Pu YZ, Liu D, Liu HS, Xiang DF, Zhang XY, Wang XY, Yang QX, Jin R, Yu RQ. Significance of arterial spin labeling in relation to sertraline treatment response in adolescents with major depressive disorder. World J Psychiatry 2025; In press

Received	2025-09-30 01:33
Peer-Review Started	2025-09-30 01:34
First Decision by Editorial Office Director	2025-11-06 08:43
Return for Revision	2025-11-06 08:43
Revised	2025-11-18 07:38
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 07:36
Articles in Press	2025-12-15 07:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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