Publication Name	World Journal of Clinical Oncology
Manuscript ID	114734
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Revisiting the anatomical pattern of bone metastases in stage IV breast cancer: Missing clinical stratification and biological depth
Manuscript Source	Invited Manuscript
All Author List	Pei-Zhi Zhang, Yan-Jie Wang and Ying-Kun Xu
Funding Agency and Grant Number
Corresponding Author	Ying-Kun Xu, Assistant Professor, MD, PhD, Department of General Surgery, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Lixia District, Jinan 250012, Shandong Province, China. yingkunxu@hotmail.com
Key Words	Imaging; Human epidermal growth factor receptor 2; Hormone receptor; Molecular subtypes; Bone metastases; Breast cancer
Core Tip	This letter highlights several overlooked aspects in a recent study on bone metastases in breast cancer, including the absence of molecular subtype stratification, survival outcomes, and lesion-level anatomical detail. We argue that incorporating imaging approaches, clinical context, and biomarker profiles is essential to make such anatomical findings more clinically meaningful and translatable.
Citation	Zhang PZ, Wang YJ, Xu YK. Revisiting the anatomical pattern of bone metastases in stage IV breast cancer: Missing clinical stratification and biological depth. World Journal of Clin Oncol 2026; In press

Received	2025-09-27 16:53
Peer-Review Started	2025-09-27 16:53
First Decision by Editorial Office Director	2025-11-18 09:54
Return for Revision	2025-11-18 09:54
Revised	2025-12-01 11:47
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 11:10
Articles in Press	2026-02-03 11:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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