Publication Name	World Journal of Psychiatry
Manuscript ID	114736
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Electroacupuncture alleviates depression and gastrointestinal dysfunction by rebalancing GABAergic activity in the central amygdala
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Kun Ma, Shan-Lan Zhu, Xue-Yan Li, Yi Yuan, Qing-Yang Huang, Hao Wang, Guo-Ming Shen and Xi-Yang Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82405244 National Natural Science Foundation of China No. 82474224 Research Project of Xin’an Medical and Chinese Medicine Modernization Research Institute No. 2023CXMMTCM016 Excellent Youth Project of Anhui Universities No. 2022AH030065 Open projects of Anhui Province Key Laboratory of Meridian Viscera Correlationship No. 2024AHMVC04
Corresponding Author	Xi-Yang Wang, PhD, College of Integrated Chinese and Western Medicine (School of Life Science), Anhui University of Chinese Medicine, No. 350 Longzihu Road, Hefei 230012, Anhui Province, China. xiyangw1@163.com
Key Words	Chronic stress; Depression; Central amygdala; GABAergic neurons; Electroacupuncture; Gastrointestinal motility; Gut-brain axis
Core Tip	This study reveals the pivotal role of central amygdala (CeA) GABAergic neurons in mediating depressive-like behavior and gastrointestinal dysfunction in mice subjected to chronic unpredictable mild stress. Chemogenetic manipulation confirmed that CeA GABAergic hyperactivation drives these comorbidities, while inhibition alleviates them. Electroacupuncture reduced depressive symptoms and gastric impairment by modulating CeA GABAergic activity. These findings highlight electroacupuncture as a promising therapy for depression with gastrointestinal comorbidity, offering new mechanistic insights into brain-gut interactions.
Citation	Ma HK, Zhu SL, Li XY, Yuan Y, Huang QY, Wang H, Shen GM, Wang XY. Electroacupuncture alleviates depression and gastrointestinal dysfunction by rebalancing GABAergic activity in the central amygdala. World J Psychiatry 2025; In press

Received	2025-09-28 10:33
Peer-Review Started	2025-09-28 10:33
First Decision by Editorial Office Director	2025-10-21 09:34
Return for Revision	2025-10-24 05:42
Revised	2025-11-06 16:11
Publication Fee Transferred	2025-11-10 04:28
Second Decision by Editor	2025-12-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-09 06:48
Articles in Press	2025-12-09 06:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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