Publication Name	World Journal of Stem Cells
Manuscript ID	114751
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Letter to the Editor
Article Title	Dawn of a new era in olfactory regeneration: Pediatric stem cell therapy enters the era of long-term validation
Manuscript Source	Invited Manuscript
All Author List	Guan-Yu Chen, Jia-Bing Kang, Yu-Kai Wang and Meng Liu
Funding Agency and Grant Number	Funding Agency Grant Number China Scholarship Council 202408520036
Corresponding Author	Meng Liu, Department of Pediatric Dentistry, Affiliated Stomatological Hospital of Xuzhou Medical University, No. 130 West Huaihai Road, Xuzhou 221000, Jiangsu Province, China. 598281227@qq.com
Key Words	Congenital olfactory disorders; Nasal epithelial stem cells; Pediatric anosmia; Stem cell therapy; Clinical translation; Regenerative medicine
Core Tip	This letter highlights a landmark prospective study that provides the first three-year follow-up evidence of autologous nasal epithelial stem cell transplantation in children with congenital olfactory disorders. The findings confirm durable efficacy and safety, transforming what was once deemed untreatable into a feasible therapeutic pathway. However, to establish this pioneering approach as a global standard, multicenter, controlled clinical trials are urgently required to validate and extend these promising results.
Citation	Chen GY, Kang JB, Wang YK, Liu M. Dawn of a new era in olfactory regeneration: Pediatric stem cell therapy enters the era of long-term validation. World J Stem Cells 2025; In press

Received	2025-10-09 16:09
Peer-Review Started	2025-10-09 16:09
First Decision by Editorial Office Director	2025-10-30 08:48
Return for Revision	2025-10-30 08:48
Revised	2025-11-02 20:12
Publication Fee Transferred
Second Decision by Editor	2025-12-08 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-08 08:58
Articles in Press	2025-12-08 08:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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