Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	114782
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Predicting the magnitude of risk for non-curative endoscopic submucosal dissection in superficial esophageal cancer using explainable artificial intelligence
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Chen Luo, Hai-Yang Guo, Xiao Tang, Xin-Rui Chen, Cheng-Yu Zhang, Yu-Tong Cui, Ji Zuo, Hao-Rui Li, Xue-Mei Hou, Hao Chen, Shao-Bi Song and Xian-Fei Wang
Funding Agency and Grant Number
Corresponding Author	Xian-Fei Wang, Chief Physician, Full Professor, Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan South Road, Shunqing District, Nanchong 637000, Sichuan Province, China. wangxianfei@nsmc.edu.cn
Key Words	Superficial esophageal cancer; Non-curative resection; Least absolute shrinkage and selection operator regression; Machine learning; Endoscopic submucosal dissection
Core Tip	This multicenter study produced an online, interpretable prediction tool that quantifies the preoperative risk of non-curative endoscopic submucosal dissection for superficial esophageal cancer. With a clear cutoff (Shapley Additive exPlanations value ≥ 0.185), it provides immediate, transparent guidance: High-risk patients are directed to radical surgery, while low-risk ones are confirmed as endoscopic submucosal dissection candidates, ensuring the first treatment choice is optimal.
Citation	Luo ZC, Guo HY, Tang X, Chen XR, Zhang CY, Cui YT, Zuo J, Li HR, Hou XM, Chen H, Song SB, Wang XF. Predicting the magnitude of risk for non-curative endoscopic submucosal dissection in superficial esophageal cancer using explainable artificial intelligence. World J Gastrointest Oncol 2025; In press

Received	2025-09-29 02:27
Peer-Review Started	2025-09-29 02:27
First Decision by Editorial Office Director	2025-10-22 09:17
Return for Revision	2025-10-23 11:11
Revised	2025-10-31 17:20
Publication Fee Transferred	2025-11-04 12:27
Second Decision by Editor	2025-12-19 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-19 07:18
Articles in Press	2025-12-19 07:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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