Publication Name	World Journal of Gastroenterology
Manuscript ID	114786
Country	Morocco

Category	Immunology
Manuscript Type	Editorial
Article Title	Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Abdellatif Bouayad
Funding Agency and Grant Number
Corresponding Author	Abdellatif Bouayad, Associate Professor, MD, Laboratory of Immunology, Mohammed First University, Faculty of Medicine and Pharmacy Oujda, 4867 Oujda l’Université, Oujda-Angad 4867, Oriental, Morocco. a.bouayad@ump.ac.ma
Key Words	Cytokines; Enzymatic biomarkers; Post-endoscopic retrograde cholangiopancreatography pancreatitis; Early diagnosis; Prognosis
Core Tip	Although high serum 4-hour amylase and lipase levels enable early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, they have limited prognostic value and lack etiological specificity. Interleukin (IL)-6 has emerged as an early inflammatory biomarker for predicting post-ERCP pancreatitis severity. Nevertheless, detection and quantification of this cytokine remain costly. Validation of rapid, cost-effective, and point-of-care IL-6 immunoassays is essential for their integration into routine clinical practice for post-ERCP pancreatitis risk prediction.
Citation	Bouayad A. Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastroenterol 2025; In press

Received	2025-09-27 16:51
Peer-Review Started	2025-09-27 16:51
To Make the First Decision
Return for Revision	2025-10-21 09:35
Revised	2025-10-28 11:21
Second Decision	2025-11-12 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 11:12
Articles in Press	2025-11-12 11:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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