Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	114791
Country	Afghanistan

Category	Surgery
Manuscript Type	Retrospective Study
Article Title	Comparative outcomes of laparoscopic vs open pancreaticoduodenectomy in early-stage pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Muhammad Kalim, Marria Sarwar, Syed Saad Ali Chishti, Muharram Ali, Saqib Qayyum, Jawad Ahmed, Murk Memon and Elham Shenawa
Funding Agency and Grant Number
Corresponding Author	Elham Shenawa, MD, Department of Oncology, Balkh University, Chuk Sancharki, Mazar-I-Sharif, Balkh 1702, Afghanistan. eshenawa@gmail.com
Key Words	Pancreatic ductal adenocarcinoma; Laparoscopic pancreaticoduodenectomy; Open pancreaticoduodenectomy; Minimally invasive surgery; Oncologic outcomes
Core Tip	Pancreaticoduodenectomy (PD) remains the cornerstone treatment for resectable pancreatic ductal adenocarcinoma, but its morbidity is substantial. Minimally invasive techniques, particularly laparoscopic PD (LPD), have emerged as alternatives to open surgery. However, evidence in early-stage pancreatic cancer is limited. In this propensity-matched analysis from a high-volume center, LPD demonstrated reduced blood loss (by 170 mL), fewer transfusions, and a shorter hospital stay (by 3 days), while showing comparable complication rates, R0 resection rates, lymph node yield, and survival outcomes to open PD. These findings suggest that LPD may be a safe and effective option in carefully selected early-stage patients, supporting its integration into surgical practice in experienced centers.
Citation	Kalim M, Sarwar M, Chishti SSA, Ali M, Qayyum S, Ahmed J, Memon M, Shenawa E. Comparative outcomes of laparoscopic vs open pancreaticoduodenectomy in early-stage pancreatic cancer. World J Gastrointest Endosc 2025; In press

Received	2025-09-28 15:07
Peer-Review Started	2025-09-28 15:07
To Make the First Decision
Return for Revision	2025-10-10 03:33
Revised	2025-10-11 14:09
Second Decision	2025-11-21 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 03:09
Articles in Press	2025-11-21 03:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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