Publication Name	World Journal of Hepatology
Manuscript ID	114804
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang-Yang Ye, Xiong-Zhi He, Zhen-Ting Hu, Feng-Feng Zheng, Xiao-Gang Huang, Xue-Mei Xie, Fei-Hua Chen, Han-Bing Ou and Rong-Xian Qiu
Funding Agency and Grant Number
Corresponding Author	Rong-Xian Qiu, Department of Infectious Diseases, The Affiliated Hospital of Putian University, No. 181 Meiyuan East Road, Putian 351100, Fujian Province, China. 18850959988@163.com
Key Words	Interferon; Neutrophil extracellular trap; Chronic hepatitis B; Hepatitis B virus; Transcriptomic and metabolomic
Core Tip	Chronic hepatitis B is a significant global health issue, and interferon (IFN) is one of the main first-line therapies for chronic hepatitis B. Non-targeted transcriptomic and metabolomic analyses revealed that IFN-related immune pathways and neutrophil extracellular trap formation were the most significantly altered pathways after IFN treatment. Core components of neutrophil extracellular traps including histones were notably increased and potentially enhance the antiviral response.
Citation	Ye XY, He XZ, Hu ZT, Zheng FF, Huang XG, Xie XM, Chen FH, Ou HB, Qiu RX. Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B. World Journal of Hepatology 2026; In press

Received	2025-09-29 02:21
Peer-Review Started	2025-09-29 05:41
First Decision by Editorial Office Director	2025-10-31 09:17
Return for Revision	2025-11-03 07:07
Revised	2025-11-11 07:13
Publication Fee Transferred	2025-11-23 06:05
Second Decision by Editor	2026-01-09 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 06:10
Articles in Press	2026-01-09 06:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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