Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	114818
Country	Saudi Arabia

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Rectal neuroendocrine tumors: Update
Manuscript Source	Invited Manuscript
All Author List	Mohammed Khayyat and Yasir M Khayyat
Funding Agency and Grant Number
Corresponding Author	Yasir M Khayyat, FACG, FACP, FRCP (C), Professor, Department of Medicine, Faculty of Medicine, Umm AL-Qura University, AlAwali District, Makkah 8156-24381, Saudi Arabia. ymkhayyat@uqu.edu.sa
Key Words	Neuroendocrine; Rectum; Metastasis; Endoscopic ultrasound; Transanal
Core Tip	This manuscript highlights that, although rare, rectal neuroendocrine tumors exhibit distinct prognostic and therapeutic profiles. Key innovations include the identification of metabolic syndrome components as risk factors, the prognostic value of vascular patterns and biomarkers such as chromogranin A as well as the refined endoscopic resection techniques showing efficacy for small tumors. Importantly, tumor grade and size are critical for predicting metastasis and survival, and local excision is often sufficient for smaller lesions.
Citation	Khayyat M, Khayyat YM. Rectal neuroendocrine tumors: Update. World J Gastrointest Oncol 2025

Received	2025-09-29 01:32
Peer-Review Started	2025-09-29 01:33
To Make the First Decision
Return for Revision	2025-10-11 03:09
Revised	2025-10-11 14:40
Second Decision	2025-11-18 01:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 07:59
Articles in Press	2025-11-18 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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