Publication Name	World Journal of Hepatology
Manuscript ID	114834
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Artificial intelligence and digital transformation of gastroenterology and hepatology: A critical review of clinical applications and future challenges
Manuscript Source	Invited Manuscript
All Author List	Miguel Suarez, Raquel Martínez, Félix González-Martínez, Ana María Torres and Jorge Mateo
Funding Agency and Grant Number
Corresponding Author	Miguel Suarez, MD, PhD, Department of Gastroenterology, Virgen de la Luz Hospital, Hermandad Donantes de Sangre, 1, Cuenca 16002, Castille-La Mancha, Spain. msuarezmatias@sescam.jccm.es
Key Words	Artificial intelligence; Machine learning; Deep learning; Natural language processing; Large language models; Neurogastroenterology; Hepatology; Inflammatory bowel disease; Endoscopy
Core Tip	Artificial intelligence (AI) is rapidly transforming gastroenterology and hepatology, offering tools that enhance diagnostic precision, personalize treatment, and reduce variability in clinical practice. Applications such as computer-aided detection in colonoscopy, non-invasive assessment of liver fibrosis, and predictive modeling in inflammatory bowel disease illustrate its tangible clinical impact. However, the widespread adoption of AI remains constrained by methodological barriers, data quality issues, lack of external validation, and ethical challenges related to transparency, accountability, and equitable access. This review provides a comprehensive overview of benefits, limitations, and future perspectives, emphasizing the importance of responsible and patient-centered integration of AI.
Citation	Suarez M, Martínez R, González-Martínez F, Torres AM, Mateo J. Artificial intelligence and digital transformation of gastroenterology and hepatology: A critical review of clinical applications and future challenges. World J Hepatol 2025; In press

Received	2025-09-29 01:45
Peer-Review Started	2025-09-29 01:45
First Decision by Editorial Office Director	2025-10-23 09:02
Return for Revision	2025-10-25 11:15
Revised	2025-11-17 22:48
Publication Fee Transferred
Second Decision by Editor	2025-12-18 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-18 06:28
Articles in Press	2025-12-18 06:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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