Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	114836
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Repeated hemorrhagic ulcers of the esophagus associated with acquired hemophilia A: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Makoto Saito, Kencho Miyashita, Masahiro Ieko, Emi Yokoyama, Minoru Kanaya, Koh Izumiyama, Akio Mori, Masanobu Morioka and Takeshi Kondo
Funding Agency and Grant Number
Corresponding Author	Makoto Saito, Chief Physician, Blood Disorders Center, Aiiku Hospital, Chuo-ku Minami 4 Nishi 25, Sapporo 064-0804, Hokkaido, Japan. ikyoku@aiiku-hp.or.jp
Key Words	Acquired hemophilia A; Gastrointestinal bleeding; Esophageal ulcer; Endoscopic hemostasis; Bypass hemostatic agent; Emicizumab; Case report
Core Tip	Acquired hemophilia A can cause life-threatening, severe bleeding. Most cases are characterized by subcutaneous or intramuscular bleeding, whereas gastrointestinal hemorrhage is rare. We report the case of a 76-year-old woman with AHA who presented with repeated bleeding from an esophageal ulcer. Endoscopic hemostasis using radiofrequency ablation was performed seven times; however, this procedure was unsuccessful. First, a mixture of factors VIIa and X (a bypass hemostatic agent) was administered, successfully controlling the hemorrhage from the esophageal ulcer. In addition, emicizumab (a substitute for activated factor VIII) was administered, after which no further bleeding was observed.
Citation	Saito M, Miyashita K, Ieko M, Yokoyama E, Kanaya M, Izumiyama K, Mori A, Morioka M, Kondo T. Repeated hemorrhagic ulcers of the esophagus associated with acquired hemophilia A: A case report. World J Gastrointest Endosc 2025; In press

Received	2025-09-29 01:49
Peer-Review Started	2025-09-29 01:49
To Make the First Decision
Return for Revision	2025-10-10 09:08
Revised	2025-10-18 09:03
Second Decision	2025-11-13 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 07:56
Articles in Press	2025-11-13 07:56
Publication Fee Transferred	2025-10-20 12:45
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ISSN	1948-5190 (online)
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