Publication Name	World Journal of Gastroenterology
Manuscript ID	114865
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Potential of lysine succinylation as a therapeutic target for gallstone formation: An insightful strategy
Manuscript Source	Invited Manuscript
All Author List	Sheng Xu and Guang-Rong Lu
Funding Agency and Grant Number	Funding Agency Grant Number Wenzhou Science and Technology Bureau No. Y20240207
Corresponding Author	Guang-Rong Lu, MD, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, No. 1111 Wenzhou Avenue, Wenzhou 325000, Zhejiang Province, China. 210257@wzhealth.com
Key Words	Cholelithiasis; Gallstone formation; Lysine succinylation; Inflammation; Adenosine monophosphate-activated protein kinase; Post-translational modification; Gallbladder
Core Tip	The mechanisms of cholelithiasis are incompletely understood. The study by Wang et al is the first to demonstrate that lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase (AMPK) inhibits gallstone formation by activating the AMPK/silent information regulator 1 pathway and suppressing inflammation and pyroptosis in gallbladder mucosal epithelial cells. This finding provides a novel therapeutic target, filling a gap in succinylation research in cholelithiasis. After obtaining meaningful conclusions from basic research, more work is needed, specifically horizontal and vertical research expansions and verification using real-world patient specimens, to bridge the gap from basic research to clinical practice.
Citation	Xu S, Lu GR. Potential of lysine succinylation as a therapeutic target for gallstone formation: An insightful strategy. World J Gastroenterol 2025; In press

Received	2025-10-09 03:23
Peer-Review Started	2025-10-09 03:23
To Make the First Decision
Return for Revision	2025-10-21 09:36
Revised	2025-11-02 08:30
Second Decision	2025-11-13 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 08:43
Articles in Press	2025-11-13 08:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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