Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	114876
Country	Algeria

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Effect of cholecystectomy on liver fat and fibrosis in metabolic dysfunction-associated steatotic liver disease patients
Manuscript Source	Invited Manuscript
All Author List	Khellaf Amalou, Nassila Belal, Abdelghani Tibouk, Yasmine Ghedada, Rym Rekab, Sabrina Fadel, Nabil Debzi and Abderezak Bousloub
Funding Agency and Grant Number
Corresponding Author	Khellaf Amalou, Assistant Professor, PhD, Department of Gastroenterology, Mohamed Seghir Nekkache, Kouba 246, Algiers 16000, Algeria. amalou_kh@yahoo.fr
Key Words	Metabolic dysfunction-associated steatotic liver disease; Cholecystectomy; Hepatic fibrosis; Metabolic dysfunction-associated steatotic liver; Metabolic dysfunction-associated steatohepatitis
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease. It is significantly linked to diabetes, obesity, and other cardiometabolic risk factors. It is more pronounced in cholecystectomized patients than in those with lithiasis. Recent research suggests that the gallbladder may help to maintain overall metabolic homeostasis. Recent data suggests that cholecystectomy (Chx) has metabolic effects and may operate as a risk factor for MASLD and metabolic syndrome. In our study, we found that Chx enhances metabolic dysfunction-associated steatotic liver and fibrosis. MASLD prevalence is higher in the Chx group than in the general population.
Citation	Amalou K, Belal N, Tibouk A, Ghedada Y, Rekab R, Fadel S, Debzi N, Bousloub A. Effect of cholecystectomy on liver fat and fibrosis in metabolic dysfunction-associated steatotic liver disease patients. World J Gastrointest Pharmacol Ther 2026; In press

Received	2025-10-01 01:50
Peer-Review Started	2025-10-01 01:50
First Decision by Editorial Office Director	2025-10-11 03:30
Return for Revision	2025-10-11 03:30
Revised	2025-12-02 00:20
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 03:54
Articles in Press	2026-02-03 03:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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