Publication Name	World Journal of Psychiatry
Manuscript ID	114882
Country	China

Category	Psychiatry
Manuscript Type	Letter to the Editor
Article Title	Critical Commentary on Initial Lurasidone Dosing Strategies in Acute Schizophrenia
Manuscript Source	Unsolicited Manuscript
All Author List	Hao-Yu Xing and Juan Yan
Funding Agency and Grant Number
Corresponding Author	Juan Yan, Manager, MD, Professor, Graduate School, Zhejiang Chinese Medical University, No. 305 Tianmushan Road, Xihu District, Hangzhou 311402, Zhejiang Province, China. 294162939@qq.com
Key Words	Lurasidone; Schizophrenia; Initial dose; Safety; Efficacy; Pragmatic trial
Core Tip	Liu et al provide evidence challenging the conventional "start low, go slow" approach for lurasidone in acute schizophrenia. Their trial suggests that initiating treatment at 80 mg/day is as safe as 40 mg/day, and may offer faster symptom control. This commentary discusses these findings in the context of prior dosing studies, emphasizing the need for tailored strategies while noting methodological constraints.
Citation	Xing HY, Yan J. Critical commentary on initial lurasidone dosing strategies in acute schizophrenia. World J Psychiatry 2025; In press

Received	2025-10-09 17:32
Peer-Review Started	2025-10-09 17:32
First Decision by Editorial Office Director	2025-10-28 09:46
Return for Revision	2025-10-28 09:46
Revised	2025-11-01 03:45
Publication Fee Transferred
Second Decision by Editor	2025-12-23 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-23 03:10
Articles in Press	2025-12-23 03:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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