Publication Name	World Journal of Clinical Oncology
Manuscript ID	114913
Country	Brazil

Category	Oncology
Manuscript Type	Review
Article Title	Immune landscape of melanoma: Tumor microenvironment, resistance mechanisms, and predictive biomarkers
Manuscript Source	Invited Manuscript
All Author List	Marina M G L Oliveira, Carol S Lemos, Mariangela L S Brazão, Alice L A Rodrigues, Evelin da C do Nascimento, Emylli M P Cardoso, Maria F F Arantes and Fabrício F de Melo
Funding Agency and Grant Number	Funding Agency Grant Number CNPq Research Productivity Fellow 309110/2025-4
Corresponding Author	Fabrício F de Melo, Assistant Professor, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, No. 58 Rua Hormindo Barros, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com
Key Words	Melanoma; Tumor microenvironment; Immunotherapy; Immune resistance; Immune checkpoints; Predictive biomarkers
Core Tip	Melanoma represents a model disease for immuno-oncology, highlighting both the efficacy and limitations of immune-based therapies. Its highly immunogenic nature, coupled with the complexity of the tumor microenvironment, drives variable treatment responses and resistance to immune checkpoint blockade and targeted therapies. By integrating insights into tumor-immune interactions, resistance pathways, and predictive biomarkers, novel therapeutic strategies, particularly rational combinations of immunotherapy, targeted agents, and next-generation immunomodulators, are paving the way toward more durable and personalized clinical outcomes.
Citation	Oliveira MMGL, Lemos CS, Brazão MLS, Rodrigues ALA, do Nascimento EDC, Cardoso EMP, Arantes MFF, de Melo FF. Immune landscape of melanoma: Tumor microenvironment, resistance mechanisms, and predictive biomarkers. World J Clin Oncol 2025; In press

Received	2025-10-01 01:52
Peer-Review Started	2025-10-01 01:52
To Make the First Decision
Return for Revision	2025-10-10 08:58
Revised	2025-10-24 03:05
Second Decision	2025-11-27 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 11:34
Articles in Press	2025-11-27 11:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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