Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	114924
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Solid dispersion of BIBR1532: A potent therapeutic for oesophageal squamous cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Juan Zhang, Nai-Xuan Deng, Huan-Qing Zhang, Jie-Zuan Cen, Zi-Xuan Zheng, Meng-Qin Guo and Zheng-Wei Huang
Funding Agency and Grant Number	Funding Agency Grant Number “Continuation” Project of Excellent Doctors, Guangdong Basic and Applied Basic Research Foundation No. 2025A04J5082 Guangdong Basic and Applied Basic Research Foundation No. 2024A1515011236
Corresponding Author	Zheng-Wei Huang, Associate Professor, PhD, College of Pharmacy, Jinan University, No. 855 East Xingye Dadao, Panyu District, Guangzhou 511443, Guangdong Province, China. huangzhengw@jnu.edu.cn
Key Words	BIBR1532; Solubility; Solid dispersion; Oesophageal squamous cancer; Hydroxypropyl methylcellulose; Druggability
Core Tip	To overcome the poor aqueous solubility and low druggability of the anti-cancer agent BIBR1532, we proposed hydroxypropyl methylcellulose (HPMC)-based solid dispersion technology for solubilisation. This approach has lower costs and risks than lipid-based formulations for large-scale manufacturing. We selected an HPMC-based strategy because of its low hygroscopicity and high glass transition temperature. These properties ensure the release and absorption of the drug in the upper gastrointestinal tract, which is a key requirement for the treatment of esophageal squamous cell carcinoma.
Citation	Zhang XJ, Deng NX, Zhang HQ, Cen JZ, Zheng ZX, Guo MQ, Huang ZW. Solid dispersion of BIBR1532: A potent therapeutic for oesophageal squamous cancer. World J Gastrointest Oncol 2025; In press

Received	2025-10-10 01:00
Peer-Review Started	2025-10-10 01:00
To Make the First Decision
Return for Revision	2025-10-23 08:35
Revised	2025-11-05 08:23
Second Decision	2025-11-20 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-20 10:33
Articles in Press	2025-11-20 10:33
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Typeset the Manuscript

ISSN	1948-5204 (online)
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