Publication Name	World Journal of Hepatology
Manuscript ID	114955
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Precision targeting of pathological angiogenesis in liver cirrhosis: Molecular mechanisms and therapeutic translation challenges
Manuscript Source	Invited Manuscript
All Author List	Biao Wen, Qiong-Ya Wang, Lan Li and Jian-Guo Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Chengdu City Medical Research Project (2022247) the High-Level Scientific Research Startup Fund Project of the First Affiliated Hospital of Chengdu Medical College (CYFY-GQ40)
Corresponding Author	Biao Wen, Chief Physician, Department of Gastroenterology, the First Affiliated Hospital of Chengdu Medical College, No. 312, Middle Section of Baoguang Avenue, Xindu District, Chengdu 610000, Sichuan Province, China. 820695761@qq.com
Key Words	Liver cirrhosis; Portal hypertension; Pathological angiogenesis; Vascular endothelial growth factor; Hepatic stellate cells; Targeted therapy; GPR116; LECT2-Tie1 signaling pathway; Hepatic hypertension-chip
Core Tip	This review systematically elaborates the central role of pathological angiogenesis in cirrhotic portal hypertension, focusing on molecular mechanisms such as the hypoxia-inducible factor-vascular endothelial growth factor axis, inflammatory stress, and local renin-angiotensin system activation. Although targeted therapies show excellent efficacy in preclinical studies, their clinical translation is hampered by three challenges: Vascular heterogeneity, activation of compensatory pathways, and risks associated with systemic administration. The article also highlights emerging strategies, including targeting novel mechanosensory receptors such as GPR116, combination therapies, and precision medicine models based on the “Hepatic Hypertension-chip”, which offer new perspectives for individualized treatment.
Citation	Wen B, Wang QY, Li L, Zhang JG. Precision targeting of pathological angiogenesis in liver cirrhosis: Molecular mechanisms and therapeutic translation challenges. World J Hepatol 2026; In press

Received	2025-10-10 01:29
Peer-Review Started	2025-10-10 01:30
First Decision by Editorial Office Director	2025-11-14 06:45
Return for Revision	2025-11-14 06:45
Revised	2025-12-29 12:39
Publication Fee Transferred
Second Decision by Editor	2026-02-13 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-13 02:56
Articles in Press	2026-02-13 02:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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