Publication Name	World Journal of Cardiology
Manuscript ID	114960
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Residual risk in atherosclerotic cardiovascular disease after statin therapy: Clinical mechanisms and management strategies
Manuscript Source	Unsolicited Manuscript
All Author List	Sze-Hua Tan, Jia-Lin Wu, Shu-Xiong Zhuo, Yi Zhang and Miao Wang
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Pudong New Area Health System Excellent Young Medical Talent Training Program No. PWRq2025-39
Corresponding Author	Miao Wang, Chief Physician, MD, PhD, Department of Internal Medicine of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Xuhui District, Shanghai 200032, China. wangmiao_126@126.com
Key Words	Atherosclerosis; Cardiovascular disease; Inflammation; Lipid metabolism; Lipoprotein(a); Residual risk; Statins; Triglycerides
Core Tip	Residual cardiovascular risk remains in patients receiving statin therapy despite well-controlled low-density lipoprotein cholesterol. Key contributors include non-high-density lipoprotein cholesterol, apolipoprotein B, lipoprotein(a), triglycerides, and persistent inflammation marked by high-sensitivity C-reactive protein and interleukin-6. Comprehensive strategies combining novel lipid-lowering therapies, anti-inflammatory treatments, lifestyle modification, and gene-silencing approaches are essential to effectively reduce residual risk and improve long-term cardiovascular outcomes.
Citation	Tan SH, Wu JL, Zhuo SX, Zhang Y, Wang M. Residual risk in atherosclerotic cardiovascular disease after statin therapy: Clinical mechanisms and management strategies. World J Cardio 2025; In press

Received	2025-10-10 06:55
Peer-Review Started	2025-10-10 06:55
First Decision by Editorial Office Director	2025-10-22 06:51
Return for Revision	2025-10-22 06:51
Revised	2025-11-05 06:28
Publication Fee Transferred
Second Decision by Editor	2025-12-18 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-18 08:56
Articles in Press	2025-12-18 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com