Publication Name	World Journal of Stem Cells
Manuscript ID	114980
Country	India

Category	Orthopedics
Manuscript Type	Editorial
Article Title	Sclerostin silencing in human umbilical cord mesenchymal stem cells enhances bone regeneration via Wnt pathway activation
Manuscript Source	Invited Manuscript
All Author List	Prashasti Sharma and Dharmendra Kumar Maurya
Funding Agency and Grant Number
Corresponding Author	Dharmendra Kumar Maurya, PhD, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, 3-82-S, A-Block, Modular Laboratory, Mumbai 400085, Maharashtra, India. dkmaurya@barc.gov.in
Key Words	Sclerostin; Mesenchymal stem cells; Wnt signaling pathway; Osteogenesis; Avascular necrosis; Glucocorticoid-induced bone disease
Core Tip	Silencing sclerostin in human umbilical cord mesenchymal stem cells enhances their bone-regenerative potential by activating the Wnt/β-catenin signaling pathway, providing a novel therapeutic approach for steroid-induced avascular necrosis of the femoral head. In the study by Lv et al, sh-human umbilical cord mesenchymal stem cells demonstrated better osteogenesis, suppressed adipogenesis, and improved bone architecture in a steroid-induced rat model compared to unmodified cells.
Citation	Sharma P, Maurya DK. Sclerostin silencing in human umbilical cord mesenchymal stem cells enhances bone regeneration via Wnt pathway activation. World J Stem Cells 2026; In press

Received	2025-10-11 09:07
Peer-Review Started	2025-10-11 09:07
First Decision by Editorial Office Director	2025-10-29 08:18
Return for Revision	2025-10-29 08:18
Revised	2025-11-10 08:58
Publication Fee Transferred
Second Decision by Editor	2026-01-15 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-15 10:13
Articles in Press	2026-01-15 10:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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