Publication Name	World Journal of Orthopedics
Manuscript ID	114991
Country	Poland

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Treatment options for patients with advanced osteoarthritis who decline knee surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Jakub Kacprzak, Robert Kołaczyński, Adam Surma, Dominik Sokalski, Jakub Piotr Adamus, Łukasz Pulik and Paweł Łęgosz
Funding Agency and Grant Number
Corresponding Author	Jakub Kacprzak, Student Scientific Association of Reconstructive and Oncology Orthopedics, Medical University of Warsaw, 61 Żwirki i Wigury St, Warsaw 02-091, Mazowieckie, Poland. k.jakub.kacprzak@gmail.com
Key Words	Knee osteoarthritis; Osteoarthritis; Conservative treatment; Practice guidelines; Non-surgical treatment
Core Tip	Among the reviewed guidelines, there is agreement on first-line therapies, specifically weight loss, exercise, and topical non-steroidal anti-inflammatory drugs (NSAIDs). Secondary treatment options, such as oral NSAIDs, intra-articular corticosteroids, and acetaminophen, are recommended but with varying support. Beyond these therapies, the guidelines provide substantially varied recommendations. Emerging therapies that are not covered by current guidelines, such as minimally invasive interventions and novel pharmacological agents, offer promising alternative strategies.
Citation	Kacprzak J, Kołaczyński R, Surma A, Sokalski D, Adamus JP, Łukasz Pulik Ł, Łęgosz P. Treatment options for patients with advanced osteoarthritis who decline knee surgery. World J Orthop 2026; In press

Received	2025-10-10 06:58
Peer-Review Started	2025-10-10 06:58
First Decision by Editorial Office Director	2025-10-21 07:42
Return for Revision	2025-10-21 07:42
Revised	2025-10-24 20:35
Publication Fee Transferred	2025-11-25 16:14
Second Decision by Editor	2026-01-14 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 06:02
Articles in Press	2026-01-14 06:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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